When I talked with my sister-in-law at Christmas time, I asked her if anything has changed for her after she lost her house and all her belongings in a fire when she and her family were on vacation (whose cause the Fire Department has still not pinpointed), and after, in the same year, she went through painful and successful breast cancer treatment.
She said, "Yes. I know now that nothing matters." I looked at her face to see if she meant that things were hopeless. I happen to have a lot of clients who come to me in a state of near hopelessness as they recount one tragedy after another over the past year or two.