The Bulls fell to the Bobcats just a week ago which should prevent any fears of the Bulls taking them lightly. Especially since Carlos Boozer is unlikely to play again [though I haven't seen official word, I doubt he plays until Saturday at the earliest].
Certainly, it's a game the Bulls should still take. The Bobcats don't have the interior muscle to really punish the Bulls as they play fairly small frequently, on top of which, the Bobcats are a dreadful road team while the Bulls have dominated at the UC so far.
Keys to the game
Derrick Rose can dominate
The Bobcats are a small team without a ton of interior shotblocking which leaves Rose in good position to score a crapload of points. If teams move to the quadruple team defense then he just needs to keep finding the open man and trusting in his teammates.
Keep bringing the defense
Derrick Rose had a triple double, but the Bulls beat the Grizzlies primarily because of some outstanding team defense. Without Boozer, the Bulls have fewer options offensively and aren't likely to perform as well. However, if they bring the defensive intensity and focus that they had yesterday against Memphis to the Bobcats tonight, it will hardly matter.
The Bobcats don't really have any great individual scoring options, so a solid team defense should limit them to pedestrian offensive output.
Luol Deng and the role players must repeat
Luol scored 28 against the Grizzlies, and while he doesn't need to score that much again, he needs to have an effective game. If he can force Jackson/Wallace/whomever he defends into as poor a game as Rudy Gay, then the Bulls will be in great shape.
The Bulls will need similar contributions from their role players. Maybe Ronnie Brewer steps up rather than Kyle Korver, or perhaps we see C.J. Watson have a quality game. One of the three needs to step up and provide some support for rose from the guard spot though.
Control the negative plays
In a home game against a bad team, if you control negative plays (offensive rebounds given up and turnovers) then you're 75% of the way towards victory. The Bulls have been sloppy with the ball at times, but the lack of using Boozer in the post should limit their turnovers they often get while feeding him.
No game is an easy game when you're missing two of your marquee players, but the Bulls should win despite their back to back.